空间组学案例文章

共 49 条
英文题目期刊影响因子(发表时)中科院分区发表年份合作单位领域物种组织类型平台DOI号
Spatial transcriptomics reveals light-induced chlorenchyma cells involved in promoting shoot regeneration in tomato callusPNAS11.11区2023北京大学现代农业研究院植物番茄愈伤组织S100010.1073/pnas.2310163120
Opportunities and Challenges in Advancing Plant Research with Single cell OmicsGenomics, Proteomics & Bioinformatics11.52区2024北京大学现代农业研究院植物综述综述S100010.1093/gpbjnl/qzae026
Harnessing spatial transcriptomics for advancing plant regeneration researchTrends in Plant Science17.31区2024香港浸会大学植物综述综述S100010.1016/j.tplants.2024.02.004
Spatial transcriptomics: Technologies, applications and experimental considerationsGenomics4.42区2023青岛大学医学院附属青岛中心医院医学综述综述S100010.1016/j.ygeno.2023.110671
Integrative molecular and spatial analysis reveals evolutionary dynamics and tumor-immune interplay of in situ and invasive acral melanomaCancer Cell50.11区2024北京大学医学部医学足底10例肢端黑色素瘤样本S1000(细胞分割)10.1016/j.ccell.2024.04.012
Spatiotemporal transcriptomics reveals key gene regulation for grain yield and quality in wheatGenome Biology10.11区2025北京大学现代农业研究院植物小麦小麦籽粒-灌浆期4天、8天、12天纵切+12天横切S100010.1186/s13059-025-03569-8
Systematic comparison of sequencing-based spatial transcriptomic methodsnature methods36.11区2024广州实验室、西湖大学医学小鼠小鼠胚胎(眼球)、成年小鼠脑(海马区)S100010.1038/s41592-024-02325-3
Spatial transcriptome analysis reveals de novo regeneration of poplar rootsHorticulture Research7.61区2024北京大学现代农业研究院植物杨树S100010.1093/hr/uhae237
haCCA: Multi-module Integrating of spatial transcriptomes and metabolomesbioRxiv//2024复旦大学肿瘤转移研究所华山医院医学小鼠肝内胆管癌模型S1000https://doi.org/10.1101/2024.08.20.608773
Molecular and spatial signatures of human and rat corpus cavernosum physiopathological processes at single-cell resolutioCell Reports7.51区2024中山大学附属第五医院医学大鼠阴茎海绵体S100010.1016/j.celrep.2024.114760
Spatiotemporal transcriptomic analyses reveal molecular gradient patterning during development and the tonotopic organization along cochlear axisbioRxiv//2025成都生物所医学小鼠E17.5+P8+2月龄小鼠耳蜗S1000https://doi.org/10.1101/2024.10.30.621022
Tracing the evolutionary and genetic footprints of atmospheric tillandsioids transition from land to airNature Communications15.71区2024浙江大学植物红苞莺哥凤梨S100010.1038/s41467-024-53756-7
Single-cell and spatial transcriptomics uncover the role of B chromosomes in driving plant invasivenessGenome Biology10.11区2026山东大学植物芦苇S300010.1186/s13059-026-04079-x
Spatiotemporal dynamics of early oogenesis in pigsGenome Biology10.11区2025青岛农业大学动物E45,E55,E65,E75猪胚胎卵巢S100010.1186/s13059-024-03464-8
Cross-species single-nucleus analysis reveals the potential role of whole-genome duplication in the evolution of maize flower developmentBMC Genomics3.52区2025北京大学现代农业研究院植物玉米雌穗+雄穗S100010.1186/s12864-024-11186-1
Obstacles in sugar transportation lead to blank nut formation in hazel (Corylus heterophylla)Industrial Crops & Products6.21区2025吉林师范大学植物榛子胚珠S1000https://doi.org/10.1016/j.indcrop.2024.120365
Spatial and single-cell transcriptomics reveal cellular heterogeneity and a novel cancer-promoting Treg cell subset in human clear-cell renal cell carcinomaJournal for ImmunoTherapy of Cancer10.31区2025第四军医大学医学肾透明细胞癌患者手术切除肿瘤组织(n=4)DG1000、S100010.1136/jitc-2024-010183
Next-generation spatial transcriptomics: unleashing the power to gear up translational oncologyMedComm10.73区2024中国科学院杭州医学研究所医学综述综述S100010.1002/mco2.765
Single-cell transcriptomics reveals the heterogeneity and function of mast cells in human ccRCCFrontiers in immunology5.72区2025第四军医大学医学肾透明细胞癌患者手术切除肿瘤组织DG1000、S100010.3389/fimmu.2024.1494025
Improving Spatial Transcriptomics with Membrane-Based Boundary Definition and Enhanced Single-Cell ResolutionSmall Methods10.72区2025广东省人民医院医学分割算法细胞膜细胞分割算法-小鼠、蝾螈:肝脏、脑、肠道S100010.1002/smtd.202401056
Single-Cell and Spatial Transcriptomics Reveals a Stereoscopic Response of Rice Leaf Cells to Mag aportheoryzae InfectionAdvanced Science14.31区2025中国农业大学植物水稻感染稻瘟病毒0、6、12、24小时后水稻叶片S100010.1002/advs.202416846
Entering the era of spatial transcriptomics: opportunities and challenges for pathologyDiagnostic Histopathology//2025牛津大学医院医学综述综述S100010.1016/j.mpdhp.2025.04.001
Integrated multi-omics analyses provide new insights into genomic variation landscape and regulatory network candidate genes associated with walnut endocarpthe plant journal6.21区2025西北大学植物核桃开花后44天核桃壳(纵切)S100010.1111/tpj.70113
A distinct subgroup with Schwann-like differentiation presents immune resistance and poor prognosis in plantar melanomaTheranostics12.41区2025北京大学第一医院医学足底黑色素瘤组织S100010.7150/thno.99526
Single-cell and spatial transcriptomics reveal the pathogenesis of chronic granulomatous disease in a natural modelcell reports7.51区2025天津医科大学基础医学院医学小鼠慢性肉芽肿病肉芽肿结构-小鼠肺组织S100010.1016/j.celrep.2025.115612
Dissection of the global responses of mandarin fish pyloric cecum to an acute ranavirus (MRV) infection reveals the formation of serositis and then ascitesJournal of Virology42区2025中山大学生命科学学院水产动物疫病防控与健康养殖全国重点实验室动物鳜鱼受感染的鳜鱼幽门盲囊S100010.1128/jvi.02308-24
CCR2+ monocytes promote memory CD8+ T-cell differentiation via membrane-bound TGF-βCellular & Molecular Immunology21.81区2025西安交通大学医学小鼠转移过继T细胞和李斯特菌第0天和第5天WT小鼠脾脏S1000、10X10.1038/s41423-025-01299-2
Spatiotemporal Transcriptomic Atlas Reveals the Regulatory Mechanisms Underlying Early Inflorescence Development and Sex Differentiation in SpinachAdvanced Science14.11区2025河南师范大学、河南农业大学植物菠菜雌/雄株,4个发育时期茎尖S100010.1002/advs.202507818
Cancer-Associated Fibroblasts Establish Spatially Distinct Prognostic Niches in Subcutaneous Colorectal Cancer Mouse ModelCancers4.43区2025西安交通大学医学院医学小鼠小鼠皮下结肠癌瘤(n=1)S100010.3390/cancers17142402
New insights into liver injury and regeneration from single-cell transcriptomicseGastroenterology//2025得克萨斯大学休斯顿健康科学中心医学综述综述S1000
The Liquid Crystal Monomer 3cH2B Affects the Visual System via Neural-Cell-Specific Retinoic Acid Disruption in the Optic TectumEnvironmental Science & Technology11.31区2025沈阳农业大学植物保护学院、中国农业科学院农产品质量标准与检测技术研究所、中国水产科学研究院淡水渔业研究中心动物斑马鱼以40天环境浓度暴露的成年斑马鱼为核心模型,系统采集了其活体、眼睛、大脑等多种样本DG1000、S1000
Dissecting cross-lineage tumourigenesis under p53 inactivation through single-cell multi-omics and spatial transcriptomicsClinical and Translational Medicine6.81区2025浙江大学医学院附属第一医院骨髓移植中心、干细胞与再生医学中心等医学小鼠小鼠胸腺S100010.1002/ctm2.70461
Single-nucleus transcriptomics reveal the morphogenesis and artemisinin biosynthesis in Artemisia annua glandular trichomesNature Communications15.71区2025海军军医大学药学院上海市药物代谢产物研究重点实验室植物黄花蒿叶片四个:4个发育阶(S1-S4)S3000、10X单细胞核转录组10.1038/s41467-025-63770-y
Advances in plant spatial multi-omics data analysisTrends in Plant Science20.81区2025浙江大学、美国佐治亚大学、密歇根大学、华大生命科学研究院植物综述综述BMKMANU10.1016/j.tplants.2025.10.005
Cellular and molecular mechanisms of seahorse male pregnancynature ecology & evolution14.51区2025南海海洋研究所、中国科学院大学、上海生物化学与细胞生物学研究所、上海科技大学、南方医科大学、昆明动物研究所、哈佛大学动物海马/海龙单细胞转录组:10 只处于不同繁殖袋发育阶段的雄性线纹海马;1 只成年雌性线纹海马。同时使用 2 只处于非妊娠及妊娠中期的成年雄性舒氏海龙以及 2 只处于非妊娠及妊娠中期的成年雄性七角海马; 单细胞 ATAC 测序: 6 个繁殖袋样本(阶段 ii、iv 和 v 各 2 个重复样本); 空间转录组测序(Spatial transcriptome-seq:1 只处于妊娠早期(阶段 v)的海马繁殖袋样本S100010.1038/s41559-025-02883-5
Spatial transcriptomics provide insights into the secondary lateral rooting difficulties of tetraploid forsythia cuttingsIndustrial Crops & Products6.21区2025内蒙古师范大学、河南农业大学植物连翘一年生二倍体和四倍体连翘扦插茎S300010.1016/j.indcrop.2025.122182
Spatially resolved single-cell transcriptome analysis of murine Salmonella infection reveals the role of distal colonocytes in the inflammatory responseGut Microbes111区2025西安交通大学医学部第一附属医院医学小鼠聚焦鼠伤寒沙门氏菌(S. Tm)感染后的小鼠结肠5 个关键时间点: Days 0, 1, 3, 5, and 7S100010.1080/19490976.2025.2579909
Electron Microscopy and Multi-Omics Reveal Mitochondrial Dysfunction and Structural Remodeling in the Hearts of Elderly MiceAging Cell7.11区2025意大利坎帕尼亚大学“路易吉·万维泰利”、IRCCS INRCA国立衰老研究中心、马尔凯理工大学医学小鼠心脏S100010.1111/acel.70286
Acquired resistance to immunotherapy by physical barriers with cancer cell-expressing collagens in non-small cell lung cancerPNAS11.11区2025四川大学华西医院、四川大学生物治疗国家重点实验室、成都中医药大学、澳门科技大学等医学小鼠后排S100010.1073/pnas.2500019122
A Single-Cell-Resolution Spatial Transcriptomic Atlas Decodes Wheat Spike Development and Yield PotentialMolecular Plant24.11区2025山东农业大学生命科学学院、北京大学现代农业研究院植物小麦小麦穗,小麦穗型建成的关键早期阶段,包括二棱早期阶段(W2.0)、二棱期阶段(W2.5)、颖片原基出现阶段(W3.0)、外稃原基出现阶段(W3.25)和小花原基出现阶段(W3.5)S300010.1016/j.molp.2025.12.020
A single-nucleus and spatial transcriptomic atlas of the shoot apex reveals insights into the vegetative-to-reproductive transition in loquatJournal of Integrative Agriculture4.41区2025华南农业大学、福建省农业科学院果树研究所植物枇杷茎尖S300010.1016/j.jia.2025.12.031
Single-Cell Transcriptomic Atlases of Camels and Cattle Unravel Molecular Evolution of Digestive and Metabolic SystemsAdvanced Science14.11区2026西北农林科技大学动物科技学院动物骆驼骆驼和牛 牛:3 头雌性荷斯坦奶牛(约 22 月龄)和 2 头雄性荷斯坦奶牛(分别为 40 日龄、5 月龄)的样品; 骆驼:3 头雌性双峰驼(约 3 岁)和 3 头雄性双峰驼(分别约 10 日龄、6 月龄、20 月龄); 单细胞 RNA 测序(scRNA-seq):C4, 如肝脏、肾脏、复胃、睾丸; 单细胞核 RNA 测序(snRNA-seq):C4,如驼峰脂肪、舌、额叶、小脑; 空间转录组:1 头成年雌性双峰驼的肾脏样品S100010.1002/advs.202519346
Integrated Single-Cell and Spatial Transcriptomics Reveal Cell-Type-Specific Immune Regulatory Networks in Maize Responding to Southern Corn RustAdvanced Science14.11区2026河南省农业科学院粮食作物研究所、河南农业大学植物保护学院、中国农业科学院作物科学研究所/作物基因资源与育种国家重点实验室、河南农业大学植物玉米玉米 叶片,接种多堆柄锈菌(处理组,PP)和模拟接种(对照组,MK)的玉米叶片,在侵染后24小时(hpi)和48小时(hpi)这两个关键早期时间S100010.1002/advs.202512295
The SWI/SNF chromatin-remodeling subunit DPF2 regulates macrophage inflammation in intestinal injury via CACNA1D-mediated MAPK pathwayPNAS9.41区2025复旦大学、苏州大学医学小鼠单细胞 RNA 测序(scRNA-seq):10X Chromium单细胞平台;从小鼠肠道中分离出固有层淋巴细胞;空间转录组:小鼠照射后肠道组织S300010.1073/pnas.2518762122
Chromatin remodeling in pericentral hepatocytes modulates MASH through CYP450 activityJournal of Hepatology331区2026苏州大学、复旦大学、南方科技大学医学小鼠单细胞RNA测序(scRNA‑seq)和单细胞核RNA测序(snRNA‑seq):对FPC饮食(果糖+棕榈酸+胆固醇)喂养4周的野生型(WT)和 Dpf2^ΔLgr5 基因型小鼠肝脏进行取样。空间转录组:FPC饮食喂养4周的 WT 和 Dpf2^ΔLgr5 小鼠。S300010.1016/j.jhep.2026.03.035
Laminar patterning transcription factors orchestrate spatial metabolite partitioning in Capsicum fruitNature plants13.61区2026北京大学现代农业研究院植物辣椒单细胞核:辣椒下胚轴、根、茎、叶片以及不同发育阶段果实;S1000/S3000+DG1000+ISSeq Kit v.1.010.1038/s41477-026-02293-w
Single-cell multiomic and spatial landscape of the primate pineal gland reveals circadian and melatonin regulatory architecturePNAS9.41区2026上海交大医学院动物食蟹猴食蟹猴松果体,21 只健康食蟹猴(雌性 9 只、雄性 12 只,4~5 龄),用于解析松果体细胞图谱与调控全景10X单细胞核RNA测序、10X单细胞ATAC、BMKMANU S300010.1073/pnas.2524839123
Super-resolution multimodal spatial transcriptomics reveals an ovoid stem-cell niche structuring de novo shoot regenerationMolecular Plant24.11区2026北京大学现代农业研究院植物番茄6 日龄幼苗子叶S1000/S3000+DG1000+ISSeq+Stereo‑seq+10× Xenium10.1016/j.molp.2026.05.008
Cross-species comparison of amniote single-cell transcriptomes reveals evolutionary conservation and divergence in the chicken immune systemNature Communications15.71区2026西北农林科技大学动物法氏囊和扁桃体S300010.1038/s41467-026-72642-y