Formalin-fixed paraffin-embedded (FFPE) samples, the most commonly used preservation format in clinical pathology, are a time capsule of invaluable biological information. However, the severe RNA degradation and protein-nucleic acid crosslinking caused by fixation have long blocked conventional technologies from accessing this wealth of information.
BMKMANU FFPE spatial transcriptomics innovatively adopts a proprietary direct poly(A) capture technology together with a patented de-crosslinking solution, precisely overcoming the key challenges of RNA degradation and protein-nucleic acid crosslinking. With high specificity and broad applicability, it offers a new approach for mining information from FFPE samples across all species.

To date the technology has been validated on human clinical FFPE samples including skin, bladder and oesophageal cancer, confirming its stability and technical feasibility across sample types. It will provide powerful and reliable support for in-depth analysis of the tumour microenvironment, screening of disease biomarkers and large-scale retrospective clinical studies.